Giants vs. Cardinals prediction, odds, spread, injuries, trends for NFL Week 2

The New York Giants season opener was a disaster. There's no sugar coating it. After a blocked field goal was returned for a touchdown on their opening drive, everything went down hill until the final whistle blew and the Dallas Cowboys walked away with the 40-0 win.

Luckily for the Giants, they now get to face the Arizona Cardinals in a perfect bounce back spot against one of the worst teams in the NFL. Can they right the ship and get a win?

I'm going to give you my best bet for this game, but if you want my pick for the other 15 games this week, check out the Week 2 edition of the "Road to 272 Bets."

If you're going to tail my pick, or if you just want some extra funds to bet with, I'd recommend signing up for an account at Caesars Sportsbook. For a limited time, you will be given $250 in bonus bets when you place your first $50 bet, win or lose! All you have to do is click the link below and sign up for an account.

Now, let's dive into my betting preview for this NFC showdown.

Giants vs. Cardinals odds, spread, and total

Giants vs. Cardinals betting trends

• Giants are 5-1 ATS in their last six road games
• Cardinals are 5-1 ATS in their last six games vs. Giants
• Cardinals have lost eight-straight games dating back to last season
• The UNDER is 5-1 in the last six meetings between these two teams
• Cardinals are 8-0 ATS in their last eight games against NFC East opponents

Giants vs. Cardinals injury reports

New York Giants injury report

• Graham Gano - K - Questionable (calf)
• Deonte Banks - CB - Questionable (cramps)
• Andrew Thomas - OT - Questionable (hamstring)
• Matt Peart - OT - Questionable (undisclosed)

Arizona Cardinals injury report

• Kelvin Beachum - OT - Questionable (undisclosed)

Giants vs. Cardinals how to watch

• Date: Sunday, Sept. 17
• Game Time: 4:05p.m. EST
• Venue: State Farm Stadium
• How to Watch (TV): FOX
• New York Giants Record: 0-1
• Arizona Cardinals Record: 0-1

Giants vs. Cardinals key players to watch

New York Giants

Daniel Jones: If the Giants are going to bounce back, they need their quarterback to play significantly better than he did in Week 1 when he completed just 53.6% of passes for 104 yards and two interceptions. Luckily, he'll be playing in much better weather against a much worse defense so I expect a strong performance.

Arizona Cardinals

Dennis Gardeck: The Cardinals defense was the MVP of their slim loss to the Commanders in Week 1, and Gardeck was a huge part of that, racking up two sacks and a forced fumble. If the Cardinals want to be competitive at all this season, playing good defense is going to be a key for them and Gardeck has proven to be a pivotal piece for them.

Giants vs. Cardinals prediction and pick

My motto for betting on Week 2 of the NFL season is "underreact." We shouldn't put too much stock in what happened in Week 1 of the season. That means I'm not going to bet against the Giants because of their terrible performance against the Cowboys on Sunday night.

Everything that could have gone wrong in that game, went wrong. Sometimes that happens.

Let's not overthink this game. We have a playoff team from last year going up against one of the worst teams in the NFL in the Cardinals. The only way Arizona can stay in this game is if their defense has another top tier performance, and I don't expect that to be the case.

Give me the Giants to win and cover on Sunday.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!