Giants Game Sunday: Giants vs Denver Broncos Odds and Prediction for Week 1 NFL Game

Daniel Jones #8 of the New York Giants looks to pass the ball against New England Patriotsat MetLife Stadium on August 29, 2021 in East Rutherford, New Jersey. (Photo by Mike Stobe/Getty Images)
Daniel Jones #8 of the New York Giants looks to pass the ball against New England Patriotsat MetLife Stadium on August 29, 2021 in East Rutherford, New Jersey. (Photo by Mike Stobe/Getty Images) /
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The Giants open the 2021 NFL season on Sunday against the Denver Broncos at MetLife Stadium in a 4:25 p.m. kickoff

The NY Giants, led by quarterback Daniel Jones, running back Saquon Barkley, and cornerback James Bradberry host the Denver Broncos, led by wide receivers Jerry Jeudy, Courtland Sutton, and defensive end Bradley Chubb in Week 1 of the NFL season on Sunday, Sept. 12, 2021 (9/12/2021) at MetLife Stadium, in a 4:25 p.m. kickoff on FOX.

It remains to be seen whether Barkley will take the field for the first time since tearing his ACL Week 2 of the 2020 season, but there is plenty of offensive firepower on both sides of the ball in this matchup.

Here’s a look at everything you need to know ahead of Sunday’s Giants vs. Broncos NFL Week 1 matchup:

Giants vs Broncos Odds Week 1

According to WynnBet, the Giants open as a 2.5-point home underdog to the Broncos, with an over/under of 42 points. Additionally, the Giants are +130 on the money line, meaning that a $100 bet on the Giants to win straight up would pay $130.

Giants vs Broncos Prediction Week 1

The Giants continue to work in new offensive line combinations, as late as the final week of practice leading up to the regular season opener against the Broncos, which could have Broncos edge rushers Von Miller and Chubb salivating. For all of the firepower on both offenses (Barkley, Shepard, Golladay, Slayton, Jeudy, Sutton, K.J. Hamler, etc.), these figure to be two of the league’s stingier defenses, which could put the under in play.

Prediction: Broncos 17-13

Make your pick today on WynnBet.com.

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Matt Lombardo is FanSided’s National NFL Insider and writes Between The Hash Marks each Wednesday. Email Matt: Matt.Lombardo@FanSided.com.