Patriots vs. Giants prediction, odds, spread, injuries, trends for NFL Week 12

The Tommy DeVito-led Giants will look to win their second straight game on Sunday when they return to MetLife Stadium to play the New England Patriots. The Giants are home underdogs on Sunday despite the Patriots losing three consecutive games. 

Should bettors trust Patriots head coach Bill Belichick to cover the spread with a struggling offense that only scored six points in their last game against the Colts? We will answer that question and more in this Week 12 contest between two teams projected to have a top-10 pick in the 2024 NFL Draft.

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Patriots vs. Giants Odds, Spread and Total

Patriots vs. Giants Betting Trends

• The Patriots are 2-8 ATS this season
• The UNDER is 2-7 in New England’s last nine games
• New York is 3-7-1 ATS this season
• The UNDER is 4-1 in New York’s last five games at home

Patriots vs. Giants Injury Reports

Patriots Injury Report

• Tyrone Wheatley Jr. - OT - IR
• Mac Jones - QB - Questionable
• DeVante Parker - WR - Questionable
• Ja’Whaun Bentley - LB - Questionable

Giants Injury Report

• Daniel Jones - QB - IR
• Evan Neal - OT - Questionable
• Bobby McCain - S - Questionable
• Adoree’ Jackson - CB - Questionable
• Darius Slayton - WR - Questionable

Patriots vs. Giants How to Watch

• Date: Sunday, Nov. 26
• Game Time: 1:00 p.m. EST
• Venue: MetLife Stadium
• How to Watch (TV): FOX
• Patriots Record: 2-8
• Giants Record: 3-8

Patriots vs. Giants Key Players to Watch

New England Patriots

Rhamondre Stevenson: Stevenson has been one of the few lone bright spots on a Patriots’ offense that lacks explosive plays and players. The 25-year-old running back has posted 482 yards and three touchdowns on 126 carries, along with 32 receptions (45 targets) for 229 yards this season.

In the Patriots’ last game against the Colts, Stevenson had 102 total yards (88 rushing) on 23 touches. The 6-foot running back has rushed for 80-plus yards in back-to-back games and has a favorable matchup against the Giants' defense (135.1 rushing yards per game allowed).

New York Giants

Saquon Barkley: The star running back is coming off a fantastic game against Washington last week. Barkley had 83 yards on 14 carries and four receptions (five targets) for 57 yards and two touchdowns. For the Giants to walk away with their fourth win, they will need another complete performance from the veteran running back. This season, Barkley has 813 total yards and five total touchdowns.

Patriots vs. Giants Prediction and Pick

It’s surprising to see New England favored by more than a field goal on Sunday, especially since there’s some uncertainty at QB. Mac Jones hasn’t played well this season and has been pulled from three games. 

Head coach Bill Belichick didn’t say who could start on Sunday in his Tuesday press conference but told all players to be ready to go, per ESPN’s Mike Reiss. Regardless, if Jones, Bailey Zappe, or Will Grier starts at QB, I don’t see the Patriots’ offense having much success. 

As for the Giants, this season has quickly unraveled due to injury, but they showed some fight in last week’s win over the Commanders. New York is 1-2-1 ATS at home this season, which isn’t great, but it’s better than the Patriots’ road ATS (1-3).

The Giants haven’t had a lot of success at home this season (1-3), which plays a part in them being underdogs. However, I think New York’s defense (21 ppg and 4.5 yards per play) can keep the Patriots’ offense at bay and hit on a couple of big plays with Barkley.

Game odds refresh periodically and are subject to change.