NY Giants vs. Bills Time, Location, Streaming, Odds & More: Everything you need to know

Is there any chance Big Blue can do the unthinkable? On Sunday night, the NY Giants, 1-4 on the season, will have the tall task of trying to take down the Bills in Buffalo. With this being a Sunday Night Football showdown, the rest of the world will have close eyes on Dexter Lawrence, Josh Allen, Stefon Diggs and others.

The Bills are coming off a loss themselves, as they weren't able to take care of business in London last weekend against the Jacksonville Jaguars. A motivated Buffalo squad is bad news for Brian Daboll and Co. In this piece, we have everything you need to know leading up to the Week 6 tilt:

What time is the NY Giants vs. Bills game?

With this being the primetime Sunday Night Football game, kickoff will be at 8:20 p.m. ET. The weather is expected to be around 50 degrees for this one as well over at Highmark Stadium.

How to watch the NY Giants vs. Bills in Week 6

If you're not going to be able to make your way to the stadium on Sunday night, you can catch the action on NBC or Universo. Streaming options are available via the NBC Sports app, NFL+, YouTube TV and fubo.TV.

NY Giants vs. Bills betting odds

Not a lot of people think the Giants will be able to keep things close, let alone pull off a win. Leading up to Sunday, the Bills are 14.5-point favorites to post a victory in Week 6. This could end up being a long night for the Giants on both sides of the ball.

Game odds refresh periodically and are subject to change.

Latest NY Giants injury news

Will Daniel Jones be able to play this weekend? Jones is dealing with a neck injury, missing practice on both Wednesday and Thursday. As for Saquon Barkley, he continues to practice on a limited basis, but it's up in the air if he'll be able to put the pads on or not vs. Buffalo.